Coeliac Disease
Persistent villous atrophy predicts development of complications and mortality in adult patients with coeliac disease - Schiepatti A, Maimaris S, Raju S et al.
Schiepatti A, Maimaris S, Raju S et al. Persistent villous atrophy predicts development of complications and mortality in adult patients with coeliac disease: a multicentre longitudinal cohort study and development of a score to identify high-risk patients. Gut 2023; 72(11): 2095-2102. doi: 10.1136/gutjnl-2023-329751.
Colon
Revealing and harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T-cells - Potenza A, Balestrieri C, Spiga M, et al.
Potenza A, Balestrieri C, Spiga M, et al. Revealing and harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T-cells. Gut 2023; 72: 1887-1903. doi: 10.1136/gutjnl-2022-328042
Endoscopy
Treatment of adenoma recurrence after endoscopic mucosal resection - Tate D, Desomer L, Argenziano M, et al.
Tate D, Desomer L, Argenziano M, et al. Treatment of adenoma recurrence after endoscopic mucosal resection. Gut 2023; 72: 1875-1886. doi: 10.1136/gutjnl-2023-330300
Technical performance and diagnostic yield of motorised spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn’s disease - Pal P, Ramchandani M, Banerjee R, et al.
Pal P, Ramchandani M, Banerjee R, et al. Technical performance and diagnostic yield of motorised spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn’s disease: a randomised controlled, open-label study (the MOTOR-CD trial) Gut 2023; 72: 1866-1874. doi: 10.1136/gutjnl-2023-329885.
Gut Brain Axis
Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases. - Konings B, Villatoro L, Van den Eynde J, et al.
Konings B, Villatoro L, Van den Eynde J, et al. Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases. Gut 2023; 72: 2103-2111. doi: 10.1136/gutjnl-2023-329685.
Helicobacter Pylori
Three-in-one single capsule bismuth quadruple therapy is more effective at three than four times daily dosing. - Pérez-Aisa A, Nyssen O, Keco-Huerga A et al.
Pérez-Aisa A, Nyssen O, Keco-Huerga A et al. Bismuth quadruple three-in-one single capsule three times a day increases effectiveness compared with the usual four times a day schedule: results from the European Registry on Helicobacter pylori Management (Hp-EuReg). Gut 2023; 72(11): 2031-2037. doi: 10.1136/gutjnl-2022-329259
Hepatology
A multiomics margin morphology classification system for hepatocellular carcinoma - Fan Z, Jin M, Zhang L, et al.
Fan Z, Jin M, Zhang L, et al. From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification. Gut 2023; 72(11): 2149-63. doi: 10.1136/gutjnl-2023-330461
Liver
Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis - Cho E, Ang C, Quek J, et al.
Cho E, Ang C, Quek J, et al. Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis. Gut 2023; 72: 2138-2148. doi: 10.1136/gutjnl-2023-330110.
Microbiota
A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut - Mishra S, Wang B, Jain S, et al.
Mishra S, Wang B, Jain S, et al. A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut. Gut 2023; 72: 1848-1865. doi: 10.1136/gutjnl-2022-327365.
Roseburia intestinalis: a new venue in immunotherapy landscape for colorectal cancer - Kang X, Liu C, Ding Y, et al.
Kang X, Liu C, Ding Y, et al. Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells. Gut 2023; 72: 2112-2122. doi: 10.1136/gutjnl-2023-330291
Oesophagus
Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis - Dellon E, Peterson K, Mitlyng B, et al.
Dellon E, Peterson K, Mitlyng B, et al. Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial Gut 2023; 72: 1828-1837. doi: 10.1136/gutjnl-2023-330337
Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis - Visaggi P, Barberio B, Del Corso G, et al.
Visaggi P, Barberio B, Del Corso G, et al. Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis. Gut 2023; 72: 2019-2030. doi: 10.1136/gutjnl-2023-329873.